Bulletin of Experimental Biology and Medicine

, Volume 89, Issue 1, pp 39–41 | Cite as

Secondary immunodeficiency associated with the use of antilymphocytic serum

  • V. T. Antonenko
  • N. I. Lisyanyi
Microbiology and Immunology
  • 13 Downloads

Abstract

A study of immune reactions of cellular and humoral types in the late stages after injection of antilymphocytic serum (ALS) showed that a state of deficiency of the humoral response to sheep's red blood cells is preserved in CBA mice. A second injection of ALS deepened the depression of the humoral immune response but had virtually no effect on survival of allografts. The results are discussed from the standpoint of the effect of ALS on immunity and the role of different mechanisms in the rejection reaction.

Key Words

antilymphocytic serum humoral immunity cellular immunity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    V. T. Antonenko, in: Pathological Physiology of Tissue Incompatibility [in Russian], Moscow (1976), pp. 5–9.Google Scholar
  2. 2.
    V. T. Antonenko, in: Immunology and Allergy [in Russian], No. 12, Kiev (1978), pp. 10–13.Google Scholar
  3. 3.
    B. D. Brondz, Byull. Éksp. Biol. Med., No. 12, 61 (1972).Google Scholar
  4. 4.
    E. V. Gubler and A. A. Genkin, The Use of Nonparametric Statistical Criteria in Medical and Biological Research [in Russian], Leningrad (1973), p. 89.Google Scholar
  5. 5.
    N. G. Serebryakov et al., in: Immunodepression during Organ Transplantation [in Russian], Moscow (1973), pp. 27–44.Google Scholar
  6. 6.
    G. G. Radzivill et al., in: Immunodepression during Organ Transplantation [in Russian], Moscow (1973), pp. 94–103.Google Scholar
  7. 7.
    A. D. Barnes and J. R. Sansom, Postgrad. Med. J.,52, 39 (1976).Google Scholar
  8. 8.
    C. Vincent and J.-P. Revillard, Transplantation,24, 141 (1977).Google Scholar
  9. 9.
    G. Gray, P. Monaco, and M. Wood, J. Immunol.,96, 229 (1966).Google Scholar
  10. 10.
    N. K. Jerne and A. A. Nordin, Science,140, 407 (1963).Google Scholar
  11. 11.
    J. Seka, S. Wacktel, and G. Murphy, Transplantation,21, 412 (1976).Google Scholar
  12. 12.
    D. Rossen et al., Nature,224, 856 (1969).Google Scholar
  13. 13.
    L. M. Wood, Transplantation,9, 122 (1970).Google Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • V. T. Antonenko
  • N. I. Lisyanyi

There are no affiliations available

Personalised recommendations