Abstract
A comparative light-optical and submicroscopic study was made of the development of strains ofToxoplasma gondii with high and low virulence in macrophages in vitro. By contrast with the active multiplication of the highly virulent strain, most toxoplasmas of the less virulent strain underwent disintegration within a few hours after penetrating into the cell, so that as a result, 24–48 h after infection, they were completely digested. Submicroscopic investigation revealed no significant morphological changes in the macrophages infected by the less virulent toxoplasmas, whereas the nuclei of macrophages infected with highly virulent toxoplasma were considerably altered. Disintegration of the parasites within the phagosome is accompanied by gradual transformation, initially of the double or triple membrane of the cyst containing the parasite into a single membrane and disappearance of the accessory layer from the mitochondria and structures of the endoplasmic reticulum surrounding the membrane of a cyst.
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Akinshina, G.T., Abakarova, É.G. & Kirillova, F.M. Fate of toxoplasma gondii in macrophages in vitro depending on virulence of the parasites. Bull Exp Biol Med 80, 1332–1335 (1975). https://doi.org/10.1007/BF00835179
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DOI: https://doi.org/10.1007/BF00835179