Abstract
Chloracizine has a marked diuretic action and increases sodium excretion in rats although not by any direct action on the kidney. This effect is accompanied by an increase in the volume of intravascular fluid, a decrease in the total plasma protein concentration, and a decrease in the hematocrit index. A study of the endogenous creatinine clearance and transport of osmotically free water shows that the mechanism of the diuretic action of chloracizine is linked chiefly with an increase in the level of glomerular filtration and decrease in the relative proximal reabsorption.
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2-Chloro-10-(3-dimethylaminopropionyl)phenothiazine-Translator.
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Vorontsov, V.V. Mechanism of the diuretic action of chloracizine. Bull Exp Biol Med 80, 1325–1328 (1975). https://doi.org/10.1007/BF00835177
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DOI: https://doi.org/10.1007/BF00835177