Abstract
An experimental model of cerebrovascular disorders of neurogenic (adrenergic) nature, arising after injection of KCl into the lateral ventricles of cats and dogs, is suggested. Surgical desympathization greatly weakened spasms of the cerebral vessels produced by the central effect of KCl. Dihydroergotoxin, phenoxybenzamine, tropaphen, octadine, and nialamide had both a therapeutic and a prophylactic effect on these exprimental disturbances of the cerebral circulation.
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Literature Cited
É. A. Bendikov, Farmakol. Toksikol., No. 6, 695 (1964).
É. A. Bendikov, “Neurogenic injuries to the myocardium and their prevention by pharmacological agents”, Candidate's Dissrtation, Moscow (1966).
A. M. Blinova and N. M. Ryzhova, Vestn. Akad. Med. Nauk SSSR, No. 5, 56 (1961).
N. K. Bogolepov, Cerebral Crises and Apoplexy [in Russian], Moscow (1971).
N. V. Kaverina, R. S. Mirzoyan, and Yu. B. Rozonov, Farmakol. Toksikol., No. 6, 689 (1965).
R. S. Mirzoyan, Farmakol. Toksikol., No. 4, 431 (1972).
R. S. Mirzoyan, Fiziol. Zh. SSSR, No. 6, 966 (1973).
R. S. Mirzoyan and Yu. M. Varentsov, Byull. Éksp. Biol. Med., No. 2, 46 (1973).
R. A. Tkachev, L. I. Aleksandrova, E. D. Markova, et al., Transient Disturbances of the Cerebral Circulation [in Russian], Moscow (1967).
C. Fieschi and L. Bozzao, in: Pharmacology of Cerebral Circulation, (ed. by A. Carpi), Pergamon, Oxford (1972), p. 11.
S. W. Holmes, Brit. J. Pharmacol.,38, 653 (1970).
D. H. Ingvar and N. A. Lassen, Triangle,9, 234 (1970).
N. A. Lassen, Circulat. Res., 34, 749 (1974).
M. J. Purves, The Physiology of the Cerebral Circulation, Cambridge University Press, Cambridge (1972).
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Mirzoyan, R.S. Prevention of cerebrovascular disorders by adrenergic drugs. Bull Exp Biol Med 80, 1322–1324 (1975). https://doi.org/10.1007/BF00835176
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DOI: https://doi.org/10.1007/BF00835176