Effect of leukocytic pyrogen on thermosensitive neurons in the anterior hypothalamus
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Unit activity in the medial preoptic and septal regions of the brain was studied in rabbits in response to changes in the local temperature and to systemic injection of leukocytic and bacterial pyrogens. A decrease in the discharge frequency of warmth receptors and activation of cold receptors were found under the influence of the pyrogens. Leukocytic pyrogen induced a faster decrease than bacterial pyrogens in the activity of warmth receptors. Temperature-neutral neurons did not respond significantly to pyrogens of either type.
Key Wordstemperature sensation neurons anterior hypothalamus pyrogens fever adjusting point
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