Mechanism of early injury to the cardiovascular system by cardiocytotoxic serum
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A combined morphological and functional study of the capillaries and small vessels of the heart and viscera (lungs, liver, kidneys, spleen, skeletal muscles, etc.) of 50 dogs was undertaken during the development of acute cytotoxic injury caused by injection of anticardiac serum (ACS) into the coronary circulation in a dose of 0.5–1.5 ml. The investigation showed that injection of ACS was followed by a widespread reaction of the microcirculation of the whole body with disturbance of capillary permeability for macromolecular compounds and considerable changes in the morphological structure of the microvessels, which were most severe in the myocardium of the left ventricle.
Key Wordsanticardiac cytotoxic serum myocardium coronary circulation capillary permeability
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