Bulletin of Experimental Biology and Medicine

, Volume 89, Issue 3, pp 340–341 | Cite as

Comparative study of the distribution of 7,12-dimethylbenz(a)anthracene in pregnant rats and their fetuses

  • L. S. Baranova
  • V. A. Aleksandrov
Oncology
  • 19 Downloads

Abstract

On the 21st day of pregnancy rats were given an intravenous injection of 7,12-dimethylbenz(a)anthracene (DMBA) in a dose of 15 mg/kg, and its concentration in the organs of the mothers (liver, kidneys, lungs, brain, spleen, and placenta) and of their fetuses (liver, kidneys, lungs, brain, intestine, carcass, and whole fetus) was determined by a fluorescence-spectral method 30, 60, and 180 min later. The highest concentration of DMBA in the mothers at all times was found in the lungs. With an increase in the time of injection the DMBA concentration fell in all organs of the pregnant rats, except in the brain, in which it rose. In the fetuses an irregular distribution of the carcinogen in the organs was found only 60 min after injection of DNBA, when the highest concentration was detected in the liver. In all fetal organs the maximal concentration was found after 60 min. Accumulation of DMBA in the various fetal organs did not correlate with the observed highest frequency of tumors in the kidney and nervous system of rat fetuses following transplacental exposure to DMBA in the same dose.

Key Words

7,12-dimethylbenz(a)anthracene placental barrier 

Literature Cited

  1. 1.
    V. A. Aleksandrov and I. A. Shendrikova, Vopr. Onkol., No. 10, 56 (1972).Google Scholar
  2. 2.
    L. N. Baranova and V. A. Aleksandrov, Byull. Éksp. Biol. Med., No. 10, 477 (1978).Google Scholar
  3. 3.
    V. A. Koblyakov, Vopr. Onkol., No. 10, 109 (1977).Google Scholar
  4. 4.
    Lo Hsin-mao, Vopr. Onkol., No. 4, 41 (1964).Google Scholar
  5. 5.
    I. A. Shendrikova, M. N. Ivanov-Galitsin, V. N. Anisimov, et al., Vopr. Onkol., No. 5, 75 (1973).Google Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • L. S. Baranova
  • V. A. Aleksandrov

There are no affiliations available

Personalised recommendations