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Effect of hydiphen on behavior and hemodynamic manifestations of emotional stress

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Hydiphen is an original Soviet tranquilizer (diphenylphosphinylacetic acid hydrazide). In a dose of 120–150 mg/kg hydiphen restores the central baroreceptor reflex regulation of arterial pressure, when depressed in cats during an acute emotional-stress reaction (confrontation with a dog). The compound has an antihypertensive antiaggressive action, and does not induce ataxia. Behavior was investigated quantitatively in animals during group interaction, using a five-point system.

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Authors and Affiliations

  1. Academy of Medical Sciences of the USSR, USSR

    M. M. Kozlovskaya (Corresponding Member)

Authors
  1. A. V. Val'dman
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  2. M. M. Kozlovskaya
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  3. I. V. Zaikonnikova
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  4. M. F. Bravkov
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  5. G. F. Rzhevskaya
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Additional information

Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow. Department of Pharmacology, First Leningrad Medical Institute. Department of Pharmacology, S. V. Kurashov Kazan' Medical Institute, Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 3, pp. 310–312, March, 1980.

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Val'dman, A.V., Kozlovskaya, M.M., Zaikonnikova, I.V. et al. Effect of hydiphen on behavior and hemodynamic manifestations of emotional stress. Bull Exp Biol Med 89, 308–311 (1980). https://doi.org/10.1007/BF00834236

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  • DOI: https://doi.org/10.1007/BF00834236

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