Changes in glycogenolysis in the zone of ischemia in experimental myocardial infarction
During the first minutes after occlusion of the coronary artery in dogs, increased glycogenolysis was detected, for which activation of phosphorylase, phosphofructokinase, triose phosphate isomerase, and lactate dehydrogenase was responsible; aldolase and glyceraldehyde-3-phosphate dehydrogenase reactions became the stages limiting the rate of glycogenolysis. Activation of glycogenolysis was evidently due to the combined action of hypoxia and catecholamines.
Key Wordsexperimental myocardial infarction glycogenolysis
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