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Effect of diazepam on epileptic activity in rats with experimental photogenic epilepsy

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of diazepam (in a dose of 4 mg/kg body weight) on the specific and nonspecific mechanisms of formation of experimental photogenic epilepsy, produced by injection of tetanus toxin into the lateral geniculate body (LGB), and the formation of a generator of pathologically enhanced excitation (GPEE) in that nucleus, was studied in chronic experiments on rats. In the above dose diazepam was found to have a relatively weak action on the degree of pathological enhancement of sensory visual stimuli in LGB in which a GPEE was formed, it facilitated the appearance of focal interictal discharges in LGB, and for 1 h it completely suppressed generalized epileptic activity in the experimental animals.

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Authors and Affiliations

  1. Academy of Medical Sciences of the USSR, USSR

    G. N. Kryzhanovskii (Corresponding member)

Authors
  1. M. B. Rekhtman
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  2. B. A. Konnikov
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  3. G. N. Kryzhanovskii
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Additional information

Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 87, No. 2, pp. 160–164, February, 1979.

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Rekhtman, M.B., Konnikov, B.A. & Kryzhanovskii, G.N. Effect of diazepam on epileptic activity in rats with experimental photogenic epilepsy. Bull Exp Biol Med 87, 142–145 (1979). https://doi.org/10.1007/BF00833972

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  • DOI: https://doi.org/10.1007/BF00833972

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