The effect of polarization on the electrical response of a muscle fiber
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Double-barrelled intracellular microlectrodes were used to determine the effect of direct-current polarization on the electrical responses of an indirectly stimulated skeletal muscle fiber membrane. Hyperpolarization increased the amplitude of spike potentials, negative after-potentials, and end-plate potentials. Depolarization had the reverse effect. The dependence of the amplitude of the electrical responses of the muscle fiber on its polarization was most pronounced when the concentration of calcium ions in the Ringer's solution was diminished. Anodal polarization interfered with the spread of excitation from the end-plate region to the adjacent fiber membrane. Polarization influences the ability of the myoneural junction to conduct the rhythmic impulses to the motor nerve.
KeywordsCalcium Skeletal Muscle Muscle Fiber Reverse Effect Myoneural Junction
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