Abstract
We investigated whether 2-[18F]-fluoro-2-de-oxy-d-glucose (FDG) and carbon-11 methionine are suitable tracers to monitor the effects of therapy for low-grade gliomas. Ten patients with low-grade glioma without previous treatment were studied with FDG positron emission tomography. Additionally,l-[methyl-11C]-methionine uptake was measured in five subjects before and 1 year after computerized tomography (CT)-guided stereotactic and computer-assisted implantation of iodine-125 seeds. All scans were 3D-matched to CT, isodose volumes were determined, and changes in glucose metabolism and methionine uptake were evaluated in tumour and brain tissue as a function of radiation dose. After 1 year glucose metabolism was not significantly altered up to a radiation dose of 300 Gy, whereas methionine uptake showed a significant dose-dependent decrease. Higher rates of decline were found in tumours with high basal methionine incorporation activity before therapy. These data suggest that measurement of methionine uptake is more suitable than measurement of FDG uptake for monitoring therapeutic effects in low-grade gliomas.
References
Bauer-Kirpes B, Sturm V, Schlegel W, Lorenz WJ. Computerized optimization of 125-1 implants in brain tumors.Int J Radiat Oncol Biol Phys 1988; 14: 1013–1023.
Wienhard K, Pawlik G, Herholz K, Wagner R, Heiss WD. Estimation of local cerebral glucose utilization by positron emission tomography of (18F)2-fluoro-2-deoxy-d-glucose: a critical appraisal of optimization procedures.J Cereb Blood Flow Metab 1985; 5: 115–125.
Pietrzyk U, Herholz K, Fink G, Jacobs A, Mielke R, Slansky I, Würker M, Heiss WD. An interactive technique for three-dimensional image registration: validation for PET, SPECT, MRI, and CT brain studies.J Nucl Med 1994; 35: 2011–2018.
Ogawa T, Uemura K, Shishido F, et al. Changes of cerebral blood flow and oxygen and glucose metabolism following radiochemotherapy of glioma — a PET study.J Comput Assist Tomogr 1988; 12: 290–297.
Rozental JM, Levine RL, Mehta MP, et al. Early changes in tumor metabolism after treatment: the effects of stereotactic radiotherapy.Int J Radiat Oncol Biol Phys 1991; 20: 1053–1060.
Ostertag CB, Warnke P, Kleihues P, et al. Iodine-125 interstitial irradiation of virally induced dog brain tumours.Neurol Res 1984; 6: 176–180.
Vaalburg W, Coenen HH, Crouzel C, et al. Amino acids for measurement of protein synthesis in vivo by PET.Nucl Med Biol 1992; 19: 227–237.
Bustany P, Chatel M, Derlon JM, et al. Brain tumor protein synthesis and histological grades: a study by positron emission tomography (PET) with [11C]L-methionine.J Neurol Oncol 1986; 3: 397–404.
Derlon JM, Bourdet C, Bustany P, Chatel M, Theron J, Darcel F, Syrota A. 11-C-l-Methionine uptake in gliomas.Neurosurgery 1989; 25: 720–728.
Kubota K, Ishiwata K, Kubota R, Yamada S, Tada M, Sato T, Ido T. Tracer feasibility for monitoring tumor radiotherapy. A quadruple tracer study with fluorine- l8-fluorodeoxyglucose or fluorine-l8-fluorodeoxyuridine,l-[methyl-14-C]methionine, [6-3-H]thymidine, and gallum-67.J Nucl Med 1991; 32: 2118–2123.
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Würker, M., Herholz, K., Voges, J. et al. Glucose consumption and methionine uptake in low-grade gliomas after iodine-125 brachytherapy. Eur J Nucl Med 23, 583–586 (1996). https://doi.org/10.1007/BF00833397
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DOI: https://doi.org/10.1007/BF00833397