Abstract
During the first 24 h after sublethal (200 rad) irradiation of mice there was a sharp decrease in the number of stem cells (to 4%), of committed precursors of granulocytes and macrophages (to 20%), and of morphologically identifiable cells (to 50%) in the bone marrow. Complete restoration of hematopoiesis ended two weeks after irradiation and was sufficient to maintain exponential growth in the number of stem cells and their intensive proliferation. The increase in the number of commited precursors was delayed until recovery of the total number of cells in the bone marrow.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
N. F. Kondratenko and I. L. Chertkov, Byull. Éksperim. Biol. Med., No. 9, 100 (1972).
N. F. Kondratenko and S. I. Shereshkov, Prob. Gematol., No. 11, 18 (1974).
A. Ya. Fridenshtein and I. L. Chertkov, The Cellular Bases of Immunity [in Russian], Meditsina, Moscow (1969).
J. E. Till and E. A. McCulloch, Radiat. Res.,14, 213 (1961).
Rights and permissions
About this article
Cite this article
Kondratenko, N.F. Kinetics of the principal parts of the hematopoietic system during postradiation regeneration. Bull Exp Biol Med 80, 1252–1254 (1975). https://doi.org/10.1007/BF00833177
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00833177