Abstract
Changes in affinity of antigen-binding receptors of lymphocytes for dinitrophenol (DNP) were studied during the primary immune response in CBA mice. The process was evaluated by the method of inhibition of rosette formation with DNP-ovalbumin-sheep's red cells complex by hapten (DNP-ε-lysine). An increase in affinity of immunoglobulin receptors on the lymphocyte surface for DNA was shown, starting from the 10th day after immunization. The question of the role of affinity and density of receptors on the surface of the immunocyte is discussed.
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Khazanova, I.V. Dynamics of lymphocyte receptor affinity for hapten during the primary immune response. Bull Exp Biol Med 80, 1224–1226 (1975). https://doi.org/10.1007/BF00833168
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DOI: https://doi.org/10.1007/BF00833168