Bulletin of Experimental Biology and Medicine

, Volume 80, Issue 4, pp 1215–1217 | Cite as

Relationship between effects of amphetamine and reserpine studied on the caudate delaying response

  • O. V. Kosheleva
Pharmacology
  • 13 Downloads

Abstract

Chronic experiments on cats showed that the effect of amphetamine in weakening the inhibitory effects of the caudate nucleus on motor activity is preserved after administration of reserpine to the animals. Weakening of the inhibitory function of the caudate nucleus in the form of increasing the thresholds of caudate delay of movements through the action of amphetamine was more marked 24 h after injection of large doses (0.3 mg/kg) of reserpine. This could be the result of increased sensitivity of dopaminergic receptors of the nigrostriatal pathways to the mediator on the denervation principle.

Key Words

basal ganglia action of amphetamine 

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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • O. V. Kosheleva

There are no affiliations available

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