Abstract
A method of determining a renin inhibitor in the plasma was developed on the principle that during successive dilution of the plasma the velocity of the renin + substrate reaction falls more slowly in the presence of inhibitor than the degree of dilution, and conversely, the reaction velocity in plasma without inhibitor is reduced more than the degree of dilution of the plasma. This principle is deduced from reaction equations suggested by Dixon and Webb (1966). The presence of renin inhibitor was demonstrated by this method in the plasma of eight of 19 intact dogs studied.
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Zhegalina, L.V., Kolchanov, N.A. & Polyak, M.G. Presence of a renin inhibitor in the plasma of intact dogs. Bull Exp Biol Med 80, 1184–1186 (1975). https://doi.org/10.1007/BF00833154
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DOI: https://doi.org/10.1007/BF00833154