Abstract
In chronic experiments (lasting up to 2 years) on dogs receiving an atherogenic diet the motor activity of the digestive tract, the cholesterol and phospholipid levels in the blood and intestinal secretion, and the morphology of the small intestine and vascular system were investigated. In the early stages of the experiments (before 4 months) elevation of the blood cholesterol level was accompanied by an increase in the periods of activity of the digestive tract, an increase in the cholesterol secretion by the small intestine, and hypertrophy of its mucosa. In the late stages of the experiments, degenerative and atrophic changes developed in the mucosa of the small intestine, motor activity of the digestive tract was disturbed, and correlation between the cholesterol levels in the blood and intestinal juice was upset. This period was characterized by high hypercholesteremia and by marked atherosclerotic changes in the blood vessels.
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Klimenko, E.D., Martsevich, M.S., Mukhina, A.P. et al. Interaction between the cardiovascular and digestive systems in the genesis of experimental atherosclerosis. Bull Exp Biol Med 80, 1164–1167 (1975). https://doi.org/10.1007/BF00833147
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DOI: https://doi.org/10.1007/BF00833147