Bulletin of Experimental Biology and Medicine

, Volume 80, Issue 4, pp 1153–1154 | Cite as

Nature of the toxic factors in burns studied in germ-free guinea pigs

  • N. A. Fedorov
  • I. K. Koryakina
  • G. I. Podoprigora
Pathological Physiology and General Pathology


Toxicity (action on migration of leukocytes in culture) of the serum and saline extracts of the internal organs after burns was studied in experiments on germ-free and contaminated guinea pigs. Despite the total absence of a microbial flora, the toxic properties of the serum and extracts of internal organs of the germ-free animals were the same as those of the contaminated guinea pigs. The results point to the important role of histiogenic factors in the development of burn toxemia.

Key Words

burns toxemia germ-free animals 

Literature Cited

  1. 1.
    I. K. Koryakina, Pat. Fiziol., No. 5, 73 (1964).Google Scholar
  2. 2.
    A. N. Orlov, Burn Infection [in Russian], Leningrad (1973).Google Scholar
  3. 3.
    N. A. Fedorov, T. V. Golosova, N. S. Murashova, et al., Pat. Fiziol., No. 2, 12 (1969).Google Scholar
  4. 4.
    N. A. Fedorov, I. K. Koryakina, and G. I. Podoprigora, Byull. Éksperim. Biol. Med., No. 8, 17 (1973).Google Scholar
  5. 5.
    L. B. Cueni, M. Allgower, et al., Z. Ges. Exp. Med.,156, 110 (1971).Google Scholar
  6. 6.
    A. Einheber, R. E. Wren, and A. S. Dobek, J. Trauma,10, 135 (1970).Google Scholar
  7. 7.
    R. P. Hummel, B. G. MacMillan, W. A. Altemeir, et al., J. Trauma,6, 368 (1966).Google Scholar
  8. 8.
    S. Sevitt, Burns, London (1957).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • N. A. Fedorov
    • 1
  • I. K. Koryakina
  • G. I. Podoprigora
  1. 1.Academy of Medical Sciences of the USSRUSSR

Personalised recommendations