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EEC concerted action on cellular degeneration and regeneration studied with PET

Modelling expert meeting blood flow measurement with PET — Orsay, 12–13 October 1989

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References

  • Bergmann SR, Fox KA, Rand AL, McElvany KD, Welch MJ, Markham J, Sobel BE (1984) Quantification of regional myocardial blood flow in vivo with H2 15O. Circulation 70:724–733

    PubMed  Google Scholar 

  • Bergmann SR, Herrero P, Markham J, Weinheimer CJ, Walsh MN (1989) Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-l5-labeled water and positron emission tomography. J Am Coll Cardiol 14:639–652

    PubMed  Google Scholar 

  • Dhawan V, Conti J, Mernyk M, Jarden JO, Rottenberg DA (1986) Accuracy of PET rCBF measurements: effect of time shift between blood and brain radioactivity curves. Phys Med Biol 31:507–514

    PubMed  Google Scholar 

  • Eichling JO, Raichle ME, Grubb RL Jr, Ter-Pogossian MM (1974) Evidence of the limitations of water as a freely diffusible tracer in brain of the rhesus monkey. Circ Res 35:358–364

    PubMed  Google Scholar 

  • Frackowiak RSJ, Lenzi GL, Jones T, Heather JD (1980) Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using15O and positron emission tomography: theory, procedure and normal values. J Comput Assist Tomogr 4:727–736

    PubMed  Google Scholar 

  • Gambhir SS, Huang SC, Hawkins RA, Phelps ME (1987) A study of the single compartment tracer kinetic model for the measurement of local cerebral blood flow using15O-water and positron emission tomography. J Cereb Blood Flow Metab 7:13–20

    PubMed  Google Scholar 

  • Herscovitch P, Raichle ME (1985) What is the correct value for the brain-blood partition coefficient for water? J Cereb Blood Flow Metab 5:65–69

    PubMed  Google Scholar 

  • Herscovitch P, Markham J, Raichle ME (1983) Brain blood flow measured with intravenous H2 15O. I. Theory and error analysis. J Nucl Med 24:782–789

    PubMed  Google Scholar 

  • Herscovitch P, Raichle ME, Kilbourn MR, Welch MJ (1987) Positron emission tomography measurement of cerebral blood flow and permeability-surface area product of water using [15O]water and [11C]butanol. J Cereb Blood Flow Metab 7:527–542

    PubMed  Google Scholar 

  • Huang SC, Carson RE, Phelps ME (1982) Measurement of local blood flow and distribution volume with short-lived isotopes: a general input technique. J Cereb Blood Flow Metab 2:99–108

    PubMed  Google Scholar 

  • Huang SC, Carson RE, Hoffman EJ, Carson J, MacDonald N, Barrio JR, Phelps ME (1983) Quantitative measurement of local cerebral blood flow in humans by positron computed tomography and15O-water. J Cereb Blood Flow Metab 3:141–153

    PubMed  Google Scholar 

  • Huang SC, Schwaiger M, Carson RE, Carson J, Hansen H, Selin C, Hoffman EJ, MacDonald N, Schelbert HR, Phelps ME (1985) Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems. J Nucl Med 26:616–625

    PubMed  Google Scholar 

  • Iida H, Kanno I, Miura S, Murakami M, Takahashi K, Uemura K (1986) Error analysis of a quantitative cerebral blood flow measurement using H2 15O autoradiography and positron emission tomography, with respect to the dispersion of the input function. J Cereb Blood Flow Metab 6:536–545

    PubMed  Google Scholar 

  • Iida H, Higano S, Tomura N, Shishido F, Kanno I, Miura S, Murakami M, Takahashi K, Sasaki H, Uemura K (1988) Evaluation of regional differences of tracer appearance time in cerebral tissues using15O-water and dynamic positron emission tomography. J Cereb Blood Flow Metab 8:285–288

    PubMed  Google Scholar 

  • Iida H, Kanno I, Takahashi A, Miura S, Murakami M, Takahashi K, Ono Y, Shishido F, Inugami A, Tomura N, Higano S, Fujita H, Sasaki H, Nakamichi H, Mizusawa S, Kondo Y, Uemura K (1988) Measurement of absolute myocardial blood flow with H2 15O and dynamic positron-emission tomography. Circulation 78:104–115

    PubMed  Google Scholar 

  • Iida H, Kanno I, Miura S, Murakami M, Takahashi K, Uemura K (1989) A determination of the regional brain/blood partition coefficient of water using dynamic positron emission tomography. J Cereb Blood Flow Metab 9:874–885

    PubMed  Google Scholar 

  • Kanno I, Lammertsma AA, Heather JD, Gibbs JM, Rhodes CG, Clark JC, Jones T (1984) Measurement of cerebral blood flow using bolus inhalation of C15O2 and positron emission tomography: description of the method and its comparison with the C15O2 continuous inhalation method. J Cereb Blood Flow Metab 4:224–234

    PubMed  Google Scholar 

  • Kanno I, Iida H, Miura S, Murakami M, Takahashi K, Sasaki H, Inugami A, Shishido F, Uemura K (1987) A system for cerebral blood flow measurement using an H2 15O autoradiographic method and positron emission tomography. J Cereb Blood Flow Metab 7:143–153

    PubMed  Google Scholar 

  • Kety SS, Schmidt CF (1946) The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest 25:476–482

    Google Scholar 

  • Knabb RM, Fox KA, Sobel RE, Bergmann SR (1985) Characterization of the functional significance of subcortical coronary stenoses with H2 15O and positron-emission tomography. Circulation 71:1271–1287

    PubMed  Google Scholar 

  • Koeppe RA, Hutchins GD, Rothley JM, Hichwa RD (1987) Examination of assumptions for local cerebral blood flow studies in PET. J Nucl Med 28:1695–1703

    PubMed  Google Scholar 

  • Lammertsma AA, Jones T, Frackowiak RSJ, Lenzi GL (1981) A theoretical study of the steady-state model for measuring regional cerebral blood flow and oxygen utilisation using oxygen-15. J Comput Assist Tomogr 5:544–550

    PubMed  Google Scholar 

  • Lammertsma AA, Frackowiak RSJ, Hoffman JM, Huang SC, Weinberg IN, Dahlbom M, MacDonald NS, Hoffman EJ, Mazziotta JC, Heather JD, Forse GR, Phelps ME, Jones T (1989) The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water. J Cereb Blood Flow Metab 9:461–470

    PubMed  Google Scholar 

  • Lammertsma AA, Cunningham VJ, Deiber MP, Heather JD, Bloomfeld P, Nutt J, Frackowiak RSJ, Jones T (1990) Combination of dynamic and integral methods for generating reproducible functional CBF images. J Cereb Blood Flow Metab (in press)

  • Meyer E (1989) Simultaneous correction for tracer arrival delay and dispersion in CBF measurements by the H2 15O autoradiographic method and dynamic PET. J Nucl Med 30:1069–1078

    PubMed  Google Scholar 

  • Raichle ME, Martin WRW, Herscovitch P, Mintun MA, Markham J (1983) Brain blood flow measured with intravenous H2 15O. II. Implementation and validation. J Nucl Med 24:790–798

    PubMed  Google Scholar 

  • Schelbert HR (1989) Myocardial ischemia and clinical applications of positron emission tomography. Am J Cardiol 64:46E-53E

    PubMed  Google Scholar 

  • Weinberg IN, Huang SC, Hoffman EJ, Araujo L, Nienaber C, Grover-McKay M, Dahlbom M, Schelbert H (1988) Validation of PET-acquired input function for cardiac studies with Rb-82. J Nucl Med 29:241–247

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Medical Research Council Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK

    Adriaan A. Lammertsma

  2. Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, F-91406, Orsay, France

    Bernard M. Mazoyer

Authors
  1. Adriaan A. Lammertsma
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  2. Bernard M. Mazoyer
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Lammertsma, A.A., Mazoyer, B.M. EEC concerted action on cellular degeneration and regeneration studied with PET. Eur J Nucl Med 16, 807–812 (1990). https://doi.org/10.1007/BF00833016

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  • DOI: https://doi.org/10.1007/BF00833016

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