Bulletin of Experimental Biology and Medicine

, Volume 54, Issue 6, pp 1406–1408 | Cite as

Morphological changes in the pancreas during the development of experimental diabetes

  • G. N. Voronin
  • Z. P. Mikhal'skaya
  • A. V. Rikkl'
Morphology And Pathomorphology


Repeated administration of small doses of alloxan (5 mg 100 g of body weight) caused diabetes to develop gradually in albino rats. A direct relationship could then be observed between the degree of disturbance of the carbohydrate metabolism and the extent of the morphological changes in the pancreas: as the blood sugar concentration in the islets of Langerhans rose, the death rate of the beta-cells also rose, and new gamma-cells were formed which developed from the “plasmodium.” Most of the medium sized and small islets were found in diabetic rats. Changes were found in the acinous cells of the “peri-insular zones,” indicating their possible transformation into islets.


Public Health Sugar Body Weight Death Rate Carbohydrate 
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Copyright information

© Consultants Bureau Enterprises, Inc. 1964

Authors and Affiliations

  • G. N. Voronin
    • 1
  • Z. P. Mikhal'skaya
    • 1
  • A. V. Rikkl'
    • 1
  1. 1.K. M. Bykov Laboratory of General Physiology and of Experimental Histology, Institute of Experimental MedicineAMN SSSRLeningrad

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