Abstract
Cutting of the teeth is disturbed in mice homozygous for the microphthalmia gene (mi/mi) and osteopetrosis develops. The effect of heparin and of parathyroid hormone on cutting of the teeth was studied in mi/mi mice. Administration of heparin from the 2nd to the 20th day in a dose of 5 units/g body weight was shown to stimulate cutting of the teeth in mi/mi mice. Combined administration of heparin, in the same doses, and parathyroid hormone led to eruption of practically the same number of teeth as heparin alone. This may be because the heparin level is deficient in mi/mi mice but secretion of parathyroid hormone is undisturbed.
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Osipov, V.V., Vakhrusheva, M.P. Effect of parathyroid hormone and heparin on dental development in mice homozygous for the microphthalmia mutation. Bull Exp Biol Med 79, 461–463 (1975). https://doi.org/10.1007/BF00832728
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DOI: https://doi.org/10.1007/BF00832728