Abstract
The ability of reversible inhibitors (galanthamine and tacrine) to protect mouse and rat brain cholinesterase from thermal denaturation when the temperature is raised to 56 and 58°C was demonstrated. The protective action was exhibited when the reversible inhibitors lowered cholinesterase activity. The resistance of the cholinesterases to heat was greater when galanthamine was used than when tacrine was used.
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Literature Cited
G. M. Grigor'eva, “The role of the anionic center of the active surface of cholinesterases,” Author's Abstract of Candidate's Dissertation, Leningrad (1965).
V. D. Tonkopii, N. V. Savateev, A. P. Brestkin, et al., Dokl. Akad. Nauk SSSR,207, No. 3, 736 (1972).
M. H. Coleman and D. D. Eley, Biochim. Biophys. Acta.,67, 646 (1963).
M. H. D. Joly, A Physico-Chemical Approach to the Denaturation of Protein, Academic Press (1965).
S. Hestrin, J. Biol. Chem.,180, 249 (1949).
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Tonkopii, V.D., Padinker, E.P. Effect of reversible inhibitors on thermal denaturation of cholinesterases. Bull Exp Biol Med 79, 400–401 (1975). https://doi.org/10.1007/BF00832708
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DOI: https://doi.org/10.1007/BF00832708