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A comparative study of the antigenic properties of certain mouse tumors inoculated into pure-brud mice

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A comparative study of the antigenic properties of the 3 transplanted mice tumors was conducted. These tumors were passed for a long period of time in inbred animals, with simultaneous tioculation of all of the 3 tumors to the same mouse. The method of specific absorption of antitumor serums was used in the reaction of complement fixation.

A clear antigenic difference of the tumor tissues from the tissues of the normal organs of the mouse, the carrier of the tumor was revealed as a result of this investigation. Besides, it was demonstrated that the antigenic substances of the cancer cells are common in different tumors. An actual difference between the antigenic properties of the 3 mice transplanted tumors was, likewise, revealed.

The use of these methods allows us to whow the fallacy of the opinion of certain foreign immunogeneticists on the absence of the specific immunity in turmors.

The above data not only make the presence of the specific antigenic substances of the pathologically changed cancer cell quite certain, but, likewise, the presence of the variations between the antigenic properties of the 3 different transplanted mice tumors.

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Authors and Affiliations

  1. Laboratory of Noninfectious Immunology Candidate for Medical Sciences, the Institute of Experimental Biology, Acad. Med. Sci. USSR, Moscow

    G. P. Airapetyan

  2. Laboratory of Antigenic Biology, Candidate for Medical Sciences, the Institute of Experimental Biology, Acad. Med. Sci. USSR, Moscow

    G. P. Airapetyan

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  1. G. P. Airapetyan
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Airapetyan, G.P. A comparative study of the antigenic properties of certain mouse tumors inoculated into pure-brud mice. Bull Exp Biol Med 44, 1372–1378 (1957). https://doi.org/10.1007/BF00830635

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  • DOI: https://doi.org/10.1007/BF00830635

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