Bulletin of Experimental Biology and Medicine

, Volume 44, Issue 5, pp 1326–1330 | Cite as

Induction of hypothermia by direct cooling of the brain through its external coverings

  • N. V. Klykov
Pathological Physiology and General Pathology


The results of experiments with the isolated over-cooling of cats' brains are described. Deep hypothermia of the brain was achieved by its overcooling with the aid of “cold blankets”. During such over-cooling the temperature of the brain is decreased more rapidly and more deeply than rectal. There is a difference in temperature between the external and internal portions of the brain. Thus, at the termination of over-cooling the temperature equalled, on the average: in the external layer of the brain (in the cortex) 18°C, in the medial layer (subcortex) 21.2°C, at the base of the brain 24.7°C and in the rectum 29°C.

Reduction of the brain temperature is associated with changes in respiration and circulation. The following increase of the temperature results in recovery of these functions. Later, no pronounced disturbances were observed in these animals.

The method of over-cooling of the brain through the external surface of the head may be used in surgical practice.


Public Health External Surface Medial Layer External Layer Brain Temperature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. [1]
    A. P. Golovin, Byull. Eksptl. Biol. i Med. 27, 3, 199–201 (1949).Google Scholar
  2. [2]
    E. V. Gubler, Byull. Eksptl. Biol. i Med. 37, 2, 34–40 (1954).Google Scholar
  3. [3]
    I. G. Zherebchenko and I. A. Peimer, Collection of Abstracts of Sci. Papers for 1950, Kirov Military med. Acad., In Russian. pp. 34–35, Leningrad 1953.Google Scholar
  4. [4]
    O. A. Karpovich, “Stimulation of the muscular and nervous systems during cooling and warming the organism,” Thesis, Omsk 1950. In Russian.Google Scholar
  5. [5]
    N. V. Klykov, “Induction of hypothermia by extracorporeal cooling of blood,” Shornik Nauchn. Trudov Kuban Skogo Medinstuta, Krasnodar 15, 73–81, (1957).Google Scholar
  6. [6]
    N. I. Kochetygov, Collection of Abstracts of Sci. Papers for 1950, Kirov Military Med. Acad., In Russian. pp. 26–27, Leningrad, 1953.Google Scholar
  7. [7]
    Nikitinov, “Lowering the body temperature of typhoid patients by cooling the neck”, M. D. Thesis, St. Petersburg 1885. In Russian.Google Scholar
  8. [8]
    B. V. Petrovsky, S. I. Babichev, and O. D. Kolyutskaya, Khirurgiya No. 9, 6–14 (1955).Google Scholar
  9. [9]
    V. M. Petrovsky, and V. M. Veisman, Proceedings of the XI Congress of the Sourthern RSFSR Branch, All-Union Soc. of Physiol., Biochem., and Pharmacol. pp. 204–205 Stavropol 1956. In Russian.Google Scholar
  10. [10]
    P. M. Starkov, Proc. 26th All-Union Congress of Surgeons, pp. 59–63 Moscow 1956. In Russian.Google Scholar
  11. [11]
    V. N. Sheinis, Freezing, Moscow 1943. In Russian.Google Scholar
  12. [12]
    W. Bigelow, C. Callaghan, A. Donald, and Scott J. McQueen, Arch. Surg., 69, 2, 208–215 (1954).Google Scholar
  13. [13]
    T. Fay, and G. W. Smith, Arch. Neurol. Psych., 45, 2, 215–224 (1941).Google Scholar
  14. [14]
    T. Fay, Med. Physics, Chicago, 1224–1228 (1944).Google Scholar
  15. [15]
    H. Swan, H. Robert, W. Virtue, S. Gilbert, and T. Kirecher, Ann. Surg. 142, 3, 382–399 (1955).Google Scholar

Copyright information

© Consultants Bureau 1957

Authors and Affiliations

  • N. V. Klykov
    • 1
  1. 1.Chair of Normal PhysiologyKuban Medical InstituteKubanUSSR

Personalised recommendations