Induction of hypothermia by direct cooling of the brain through its external coverings
- 22 Downloads
The results of experiments with the isolated over-cooling of cats' brains are described. Deep hypothermia of the brain was achieved by its overcooling with the aid of “cold blankets”. During such over-cooling the temperature of the brain is decreased more rapidly and more deeply than rectal. There is a difference in temperature between the external and internal portions of the brain. Thus, at the termination of over-cooling the temperature equalled, on the average: in the external layer of the brain (in the cortex) 18°C, in the medial layer (subcortex) 21.2°C, at the base of the brain 24.7°C and in the rectum 29°C.
Reduction of the brain temperature is associated with changes in respiration and circulation. The following increase of the temperature results in recovery of these functions. Later, no pronounced disturbances were observed in these animals.
The method of over-cooling of the brain through the external surface of the head may be used in surgical practice.
KeywordsPublic Health External Surface Medial Layer External Layer Brain Temperature
Unable to display preview. Download preview PDF.
- A. P. Golovin, Byull. Eksptl. Biol. i Med. 27, 3, 199–201 (1949).Google Scholar
- E. V. Gubler, Byull. Eksptl. Biol. i Med. 37, 2, 34–40 (1954).Google Scholar
- I. G. Zherebchenko and I. A. Peimer, Collection of Abstracts of Sci. Papers for 1950, Kirov Military med. Acad., In Russian. pp. 34–35, Leningrad 1953.Google Scholar
- O. A. Karpovich, “Stimulation of the muscular and nervous systems during cooling and warming the organism,” Thesis, Omsk 1950. In Russian.Google Scholar
- N. V. Klykov, “Induction of hypothermia by extracorporeal cooling of blood,” Shornik Nauchn. Trudov Kuban Skogo Medinstuta, Krasnodar 15, 73–81, (1957).Google Scholar
- N. I. Kochetygov, Collection of Abstracts of Sci. Papers for 1950, Kirov Military Med. Acad., In Russian. pp. 26–27, Leningrad, 1953.Google Scholar
- Nikitinov, “Lowering the body temperature of typhoid patients by cooling the neck”, M. D. Thesis, St. Petersburg 1885. In Russian.Google Scholar
- B. V. Petrovsky, S. I. Babichev, and O. D. Kolyutskaya, Khirurgiya No. 9, 6–14 (1955).Google Scholar
- V. M. Petrovsky, and V. M. Veisman, Proceedings of the XI Congress of the Sourthern RSFSR Branch, All-Union Soc. of Physiol., Biochem., and Pharmacol. pp. 204–205 Stavropol 1956. In Russian.Google Scholar
- P. M. Starkov, Proc. 26th All-Union Congress of Surgeons, pp. 59–63 Moscow 1956. In Russian.Google Scholar
- V. N. Sheinis, Freezing, Moscow 1943. In Russian.Google Scholar
- W. Bigelow, C. Callaghan, A. Donald, and Scott J. McQueen, Arch. Surg., 69, 2, 208–215 (1954).Google Scholar
- T. Fay, and G. W. Smith, Arch. Neurol. Psych., 45, 2, 215–224 (1941).Google Scholar
- T. Fay, Med. Physics, Chicago, 1224–1228 (1944).Google Scholar
- H. Swan, H. Robert, W. Virtue, S. Gilbert, and T. Kirecher, Ann. Surg. 142, 3, 382–399 (1955).Google Scholar