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Bulletin of Experimental Biology and Medicine

, Volume 88, Issue 6, pp 1477–1479 | Cite as

Cellular regulation of secretion of mitogenic factor by human lymphocytes in vitro

  • N. N. Voitenok
  • N. V. Varivotskaya
Experimental Biology

Abstract

The principles governing production of mitogenic factor in human lymphocyte cultures stimulated by phytohemagglutinin (PHA) were studied. The mitogenic activity of the culture media were tested in the presence of antibodies against PHA. Irradiation of the lymphocytes sharply increased their ability to produce mitogenic factors. Removal of phagocytic cells by means of iron carbonyl also led to marked stimulation of production of the factor. Irradiations and removal of phagocytic cells were shown to stimulate production of mitogenic factor by different mechanisms.

Key Words

lymphokines mitogenic factor 

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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • N. N. Voitenok
  • N. V. Varivotskaya

There are no affiliations available

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