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Bulletin of Experimental Biology and Medicine

, Volume 88, Issue 6, pp 1459–1462 | Cite as

Specifically reactive cells in experimental allergic pertussis encephalomyelitis

  • V. B. Gervazieva
  • A. A. Babakhin
  • V. V. Sveranovskaya
Allergology
  • 15 Downloads

Abstract

The dynamics of appearance of cells specifically reactive to brain antigen (SRC) in the regional lymph nodes and peripheral blood was studied in guinea pigs with experimental allergic pertussis encephalomyelitis (EAE). In the middle of the incubation period of EAE (the 6th–7th day) the largest number of SRC was found in the regional lymph nodes, and this was followed by a marked decline until the 9th day of sensitization, whereas the greatest number of SRC in the peripheral blood was observed at this time. In the period of clinically marked EAE (20th day) the number of SRC in the regional lymph nodes was increased, whereas the number in the peripheral blood was reduced. It is concluded that the SRC discovered may belong to the population of T-lymphocytes.

Key Words

allergic encephalomyelitis specifically reactive cells 

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Literature Cited

  1. 1.
    V. B. Gervazieva, A. A. Babakhin, and A. Kh. Kanchurin, in: International Congress of Neuropathology, Budapest (1975), pp. 149–152.Google Scholar
  2. 2.
    A. Kh. Kanchurin, A. A. Babakhin, and V. B. Gervazieva, Patol. Fiziol., No. 5, 15 (1973).Google Scholar
  3. 3.
    D.-H. Adda, E. Beraud, and B. Depieds, Eur. J. Immunol.,7, 620 (1977).Google Scholar
  4. 4.
    A. C. Allison, Boll. Ist. Sieroter. Milan.,53, 123 (1974).Google Scholar
  5. 5.
    C. C. Bernard, J. Leydon, and J. R. Mackay, Eur. J. Immunol.,6, 655 (1976).Google Scholar
  6. 6.
    C. C. Bernard, I. Roberts, and J. R. Mackay, J. Immunogenet.,4, 277 (1977).Google Scholar
  7. 7.
    S. Hruby, E. C. Alvord, and C. M. Shaw, Int. Arch. Allergy,36, 599 (1969).Google Scholar
  8. 8.
    M. W. Kies, Ann. N.Y. Acad. Sci.,122, 161 (1965).Google Scholar
  9. 9.
    S. Orgad and J. R. Cohen, Science,183, 1083 (1974).Google Scholar
  10. 10.
    L. Ortiz-Ortiz and W. O. Weigle, J. Exp. Med.,144, 604 (1976).Google Scholar
  11. 11.
    L. Steiman, J. R. Cohen, L. Teitelbaum, et al., Nature,265, 173 (1977).Google Scholar
  12. 12.
    J. E. Swierkosz and R. H. Swanborg, J. Immunol.,115, 631 (1975).Google Scholar
  13. 13.
    U. Traugott and C. S. Raine, Cell. Immunol.,34, 146 (1977).Google Scholar
  14. 14.
    U. Traugott, S. H. Stone, and C. S. Raine, J. Neurol. Sci.,36, 55 (1978).Google Scholar
  15. 15.
    A. A. Vandenbark and D. J. Hinrichs, Cell Immunol.,12, 85 (1974).Google Scholar
  16. 16.
    A. M. Welch and R. H. Swanborg, Eur. J. Immunol.,6, 910 (1976).Google Scholar
  17. 17.
    L. Yung, E. Diener, T. A. McPherson, et al., J. Immunol.,110, 1383 (1973).Google Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • V. B. Gervazieva
  • A. A. Babakhin
  • V. V. Sveranovskaya

There are no affiliations available

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