Bulletin of Experimental Biology and Medicine

, Volume 88, Issue 6, pp 1452–1455 | Cite as

Role of T- and B-lymphocytes in heterogeneity of cell-mediated reactions to bacterial antigens in man

  • D. K. Novikov
  • V. I. Novikova
Microbiology and Immunology


Blood leukocytes from 30 patients with allergy to tuberculin and bacterial antigens were treated with antithymus (ATS) or anti-immunoglobulin serum (AIGS), after which the leukocyte migration inhibition (LMI) test was carried out with these antigens. ATS abolished LMI by tuberculin and sometimes by bacterial antigens (staphylococcal, streptococcal, etc.). AIGS frequently abolished LMI caused by bacterial antigens but not by tuberculin. In other cases treatment with any serum abolished LMI by antigens or, conversely, it was abolished only by treatment with both antisera in turn. The type of lymphocytes (T or B) determining the reaction to the same antigen in the secondary immune response differed in different patients and also differed in the same patient for different antigens. Five types of interaction between lymphocytes and antigen in the LMI test were distinguished.

Key Words

T- and B-lymphocytes cell-mediated reaction antithymus and anti-immunoglobulin serum immune response to bacterial antigens hypersensitivity of delayed type (HDT) 


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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • D. K. Novikov
  • V. I. Novikova

There are no affiliations available

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