Abstract
Experiments on rats showed that chronic administration of the β-adrenoblocker propranolol in doses blocking glycogenolytic and lipolytic effects of exogenous adrenalin, does not prevent the fall in the glycogen level in the liver and myocardium and the rise in the serum free fatty acid level and in the lipolytic activity of adipose tissue in vitro arising under the influence of large doses of thyroxine.
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Literature Cited
L. M. Gol'ber and V. I. Kandror, Ter. Arkh., No. 5, 59 (1977).
L. M. Gol'ber, V. I. Kandror, and I. V. Kryukova, in: Current Problems in Diabetology and Diseases of the Thyroid Gland [in Russian], Kishinev (1977), pp. 19–20.
G. A. Bray, Endocrinology,79, 554 (1966).
V. J. Cairoli and J. R. Crout, J. Pharmacol. Exp. Ther.,158, 55 (1967).
A. F. Debons and I. L. Schwartz, J. Lipid Res.,2, 86 (1961).
W. G. Duncombe, Clin. Chim. Acta.,9, 122 (1964).
V. Felt and J. Nedvidkova, Vnitrni Lek.,18, 374 (1973).
M. E. Hess and J. Shanfeld, J. Pharmacol. Exp. Ther.,148, 290 (1965).
V. I. Kandror and I. V. Kryukova, in: Abstracts of the 3rd International Congress of Pathological Physiology, Varna, Bulgaria (1978), p. 177.
G. S. Levey, Am. J. Med.,50, 413 (1971).
G. S. Levey, Med. Clin. N. Am.,59, 1193 (1975).
D. G. McDewitt, R. G. Shanks, D. R. Hadden, et al., Lancet,1, 998 (1968).
S. Seifter, S. Dayton, B. Novic, et al., Arch. Biochem.,25, 191 (1950).
A. I. Vinik, B. L. Pimstone, and R. Hoffenberg, Metabolism,19, 93 (1970).
L. T. Williams, R. J. Lefkowitz, A. M. Watanabe, et al., J. Biol. Chem.,252, 2787 (1977).
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Arslanov, S.N., Kryukova, I.V. & Kandror, V.I. Role ofβ-adrenoreception in realization of glycogenolytic and lipolytic effects of an excess of thyroid hormones. Bull Exp Biol Med 88, 1410–1413 (1979). https://doi.org/10.1007/BF00830346
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DOI: https://doi.org/10.1007/BF00830346