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The relation of the site of action of the antigen in the body and the site of antibody formation

(In experimental immunization with tetanus toxoid) Communication III. A comparison of the value of intramuscular and intravenous injection of toxoid and the importance in immunization of antigen circulating in the blood

  • Microbiology and Immunity
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The content of toxoid was investigated in the blood serum in certain methods of intravenous and intramuscular immunization. The period of circulation of the antigen in the blood as well as its possible qualitative changes were examined. The data obtained permit the belief that toxoid circulating in the blood is of secondary significance in the primary immunizational reactions of the organism. The effect of antigen on the regional lymph nodes or on the tissues at the site of injection should be considered as a decisive factor. The question of dependence of the place of action of the antigen on its physicochemical structure is discussed.

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Authors and Affiliations

  1. The Laboratory of Pathology of Infectious Diseases of the Department of General Pathology of the Institute of Normal and Pathological Physiology of the Academy of Medical Sciences, Moscow, USSR

    L. N. Fontalin

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  1. L. N. Fontalin
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Fontalin, L.N. The relation of the site of action of the antigen in the body and the site of antibody formation. Bull Exp Biol Med 45, 716–721 (1958). https://doi.org/10.1007/BF00824592

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  • DOI: https://doi.org/10.1007/BF00824592

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