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The effect of paraverine and dibazol on the rate of the coronary circulation

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The effect of papaverine and dibazol on the coronary blood flow was studied in short-term experiments on cats, anesthetized with nembutal in condition of artificial respiration. A method which allowed determination of the volume velocity of blood outflow from the coronary sinus was employed. Papaverine provokes a pronounced increase of the coronary blood flow. Dibazol on the other hand, causes only insignificant and temporary increase. When paraverine was administered after dibazol its effect on the coronary blood vessels was enhanced. Thus, combined administration of papaverine and dibazol reinforces their effect.

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Author information

Authors and Affiliations

  1. The Laboratory of Regional Pharmacology of the Institute of Pharmacology and Chemotherapy of the Academy of Medical Sciences, Moscow, USSR

    I. E. Kisin

Authors
  1. I. E. Kisin
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Additional information

Dibazol is 2-benzyl-benzimidazol hydrochloride — Publisher's note.

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Kisin, I.E. The effect of paraverine and dibazol on the rate of the coronary circulation. Bull Exp Biol Med 45, 712–715 (1958). https://doi.org/10.1007/BF00824591

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  • DOI: https://doi.org/10.1007/BF00824591

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