Summary
A comparative study was carried out on the active concentrations of certain antibiotics in the lymph of the peripheral vessels and in the lymph of the thoracic duct. Experiments were performed on dogs. Antibiotics under investigation were introduced intravenously in a single dose (10,000 units/kg penicillin, 10 mg/kg biomycin, tetracycline and terramycin). Active concentrations of all of these antibiotics are as a rule lower in the lymph of the duct of the head than in the lymph of the thoracic duct. Conclusion may be drawn that the study of concentration of antibiotics in tissue fluids of the organism must be based on determinations of their concentration in the lymph of peripheral vessels and not in the lymph of the thoracic duct.
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Ivanova, G.A. Comparison of the active concentrations of some antibiotics in the lymph of the peripheral vessels and the thoracic duct. Bull Exp Biol Med 45, 701–704 (1958). https://doi.org/10.1007/BF00824588
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DOI: https://doi.org/10.1007/BF00824588