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Synthesis and biological activity of some new pyridazine derivatives

Synthese und biologische Aktivität einiger neuer Pyridazinderivate

  • Organische Chemie Und Biochemie
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Summary

Condensation of β-aroyl-α-[1,3-diphenyl-5(4H)-oxo-pyrazol-4-yl] propionic acid with hydrazine hydrate affords 4,5-dihydro-3(2H)-pyridazinone (2). Reaction of2 with POCl3 and P2S5 gives a dichloro derivative (7) and a dithione (4). The behavior of the dichloro and dithione derivatives toward various reagents was studied. Thein vitro antibacterial screening reveals moderate activities against certain bacteria.

Zusammenfassung

Kondensation von β-Aroyl-α-[1,3-diphenyl-5(4H)-oxo-pyrazol-4-yl]-propionsäure mit Hydrazinhydrat ergibt 4,5-Dihydro-3(2H)-pyridazinon (2). Reaktion von2 mit POCl3 und P2S5 liefert ein Dichlorderivat (7) und ein Dithion (4). Das Verhalten dieser beiden Verbindungen gegenüber verschiedenen Reagentien wurde untersucht. Antibakterielles screening (in vitro) ergab mäßige Aktivität gegenüber verschiedenen Bakterienstämmen.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt

    E. AbdEl-Ghani, M. G. Assy & H. Y. Moustafa

Authors
  1. E. AbdEl-Ghani
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  2. M. G. Assy
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  3. H. Y. Moustafa
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AbdEl-Ghani, E., Assy, M.G. & Moustafa, H.Y. Synthesis and biological activity of some new pyridazine derivatives. Monatsh Chem 126, 1265–1270 (1995). https://doi.org/10.1007/BF00824306

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  • DOI: https://doi.org/10.1007/BF00824306

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