Cardiovascular Drugs and Therapy

, Volume 10, Issue 2, pp 185–187 | Cite as

Diltiazem and verapamil prevent vitamin D3-induced myocardial calcium overload in rat papillary muscle: Assessment with PVC ETH-123 calcium-selective microelectrodes

  • R. Gasser
  • Y. K. Byon
  • G. Frey
  • G. Fleckenstein-Grün
  • A. Fleckenstein
Letter to the Editor

Key words

myocardium diltiazem calcium antagonist microelectrode 

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References

  1. 1.
    Fleckenstein A, Frey M, Fleckenstein-Grün G. Consequences of uncontrolled calcium entry and its prevention with calcium antagonists.Eur Heart J 1983;4(Suppl H): 48–50.Google Scholar
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    Gasser R. Advances in construction and methods of application of calcium ion-selective microelectrodes.Selective Electrode Rev 1988;10:49–70.Google Scholar
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    Gasser R, Vaughan-Jones RD. Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle.J Physiol 1990;431: 713–741.PubMedGoogle Scholar
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    Gasser R, Frey M, Byon YK, Fleckenstein-Grün G. Restriction by nitrendipine of excessive concentrations of free intracellular calcium ions in ventricular myocardium of hypertensive rats.Angiology 1988;39:246–252.PubMedGoogle Scholar
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    Gasser R, Frey M, Fleckenstein-Grün G. Free calcium in rat papillary muscle at contraction assessed with Ca-selective microelectrodes.Angiology 1989;40:736–741.PubMedGoogle Scholar
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    Tsien RY, Rink TJ. Ca-selective electrodes: A novel PVC-gelled neutral carrier mixture compared with other currently available sensors.J Neurosci Methods 1981:4:73–86.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • R. Gasser
    • 1
  • Y. K. Byon
    • 2
  • G. Frey
    • 2
  • G. Fleckenstein-Grün
    • 2
  • A. Fleckenstein
    • 2
  1. 1.Experimental CardiologyMedizinische Universitätsklinik GrazGrazAustria
  2. 2.Physiologisches InstitutUniversität FreiburgFreiburgFRG

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