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Physiological significance and bioenergetic aspects of glucose dehydrogenase

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Abstract

The regulation of the PQQ-linked glucose dehydrogenase in different organisms is reviewed. It is concluded that this enzyme functions as an auxiliary energy-generating mechanism, because it is maximally synthesized under conditions of energy stress. It is now definitively established that the oxidation of glucose to gluconate generates metabolically useful energy. The magnitude of the contribution of the oxidation of glucose to gluconate via this enzyme to the growth yield of organisms such asAcinetobacter calcoaceticus is not yet clear.

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Authors and Affiliations

  1. Department of Microbiology, Biotechnology Centre, University of Amsterdam, Amsterdam, The Netherlands

    Oense M. Neijssel & Ronald W. J. Hommes

  2. Department of Biochemistry, Biotechnology Centre, University of Amsterdam, Amsterdam, The Netherlands

    Pieter W. Postma

  3. Microbiology, University of Sheffield, S10 2TN, Sheffield, England

    David W. Tempest

Authors
  1. Oense M. Neijssel
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  2. Ronald W. J. Hommes
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  3. Pieter W. Postma
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  4. David W. Tempest
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Neijssel, O.M., Hommes, R.W.J., Postma, P.W. et al. Physiological significance and bioenergetic aspects of glucose dehydrogenase. Antonie van Leeuwenhoek 56, 51–61 (1989). https://doi.org/10.1007/BF00822584

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