Virchows Archiv A

, Volume 414, Issue 3, pp 273–277 | Cite as

Human chorionic gonadotrophin expression and histological findings as predictors of response to radiotherapy in carcinoma of the bladder

  • J. E. Martin
  • B. J. Jenkins
  • R. J. Zuk
  • R. T. D. Oliver
  • S. I. Baithun
Article

Summary

A retrospective analysis of the prognostic value of pretreatment histology and expression of human chorionic gonadotrophin (B-hCG) was carried out in 100 invasive (T2/T3) transitional cell carcinomas of the bladder treated in a uniform manner. After transurethral resection of the tumour, all patients received a course of radical radiotherapy, with salvage cystectomy for those who failed to respond. Forty-nine of 100 patients responded to radiation; thus 51 did not. Forty-seven of 60 (78%) patients whose tumours contained areas of squamous differentiation and 22 of 29 (76%) of tumours staining positively for HCG failed to respond to radiotherapy. Twenty-two of 23 (96%) patients with tumours that had both these features did not respond to radiotherapy. The other histological features studied (grade of tumour, necrosis, inflammation, vascular invasion, and growth pattern) appeared unrelated to each other or to clinical outcome.

Key words

Transitional cell carcinoma Bladder Squamous metaplasia Human chorionic gonadotrophin Radiotherapy Prognosis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blandy JP, England HR, Evans JW, Hope-Stone HF, Mair GMM, Mantell BS, Oliver RTD, Paris AMI, Risdon RA (1980) T3 bladder cancer - the case for salvage cystectomy. Br J Urol 52:506–510Google Scholar
  2. Boileau MA, Johnson DE, Chan RC, Gonzales MO (1980) Bladder carcinoma. Results with preoperative radiation therapy and radical cystectomy. Br J Urol 16:569–576Google Scholar
  3. Braunstein GD, Vaitukaitis JL, Carbone PP, Ross GT (1973) Ectopic production of human chorionic gonadotrophin by neoplasms. Ann Intern Med 78:39–45Google Scholar
  4. Campo E, Palacin A, Benasco C, Quesada E, Cardesa A (1985) Human chorionic gonadotrophin in colorectal carcinoma, an immunohistochemical study. Cancer 59:1611–1616Google Scholar
  5. Collino C, Stephenson C, Baithun SI, Cox E, Chard T, Oliver RTD (1986) Human chorionic gonadotrophin production by transitional cell carcinoma of the bladder. Abstract J Pathol 149:248Google Scholar
  6. Crocker J, Smith PJ (1984) Immunohistochemical localisation of factor VIII related antigen in Hodgkins disease. J Clin Pathol 37:37–44Google Scholar
  7. Hope-Stone HF (1986) Urothelial malignancies. In: Hopestone HF (ed) Radiotherapy in clinical practice. Chapter 3, London, Butterworth, pp 27–68Google Scholar
  8. Jenkins BJ, Caulfield MJ, Fowler CG, Badenoch DF, Tiptaft RC, Oliver RTD, Blandy JPB (1988) Reappraisal of the role of radical radiotherapy and salvage cystectomy in the treatment of invasive T2/T3 bladder cancer. Br J Urol 62:343–347Google Scholar
  9. Jewett HJ, King LR, Shelley WM (1964) A study of 365 cases of infiltrating bladder cancer; relation of certain pathological characteristics to prognosis after extirpation. J Urol 92:668–678Google Scholar
  10. Pomerance A (1972) Pathology and prognosis following total cystectomy for carcinoma of the bladder. Br J Urol 44:451–458Google Scholar
  11. Rodenburg CJ, Nieuwenhuyzen Kruseman AC, DeMaaker HA, Fieuren EJ, Van Oosterom AT (1985) Immunohistochemical localisation and chromatographic characterisation of human chorionic gonadotrophin in a bladder carcinoma. Arch Pathol Lab Med 109:1046–1049Google Scholar
  12. Shah VM, Newman J, Crocker J, Chapple CR, Collard MJ, O'Brien JM, Considine JC (1986) Arch Pathol Lab Med 110:107–111Google Scholar
  13. Slack NH, Prout GR (1980) The heterogeneity of invasive bladder carcinoma and different responses to treatment. J Urol 123:644–652Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • J. E. Martin
    • 1
  • B. J. Jenkins
    • 1
  • R. J. Zuk
    • 1
  • R. T. D. Oliver
    • 1
  • S. I. Baithun
    • 1
  1. 1.Departments of Morbid Anatomy and UrologyThe London HospitalWhitechapelUK

Personalised recommendations