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Etoposide phosphate, the water soluble prodrug of etoposide

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Abstract

Etoposide (Vepesid) is a widely used drug in a variety of neoplasms. To improve the pharmaceutical characteristics of etoposide, etooside phosphate (Etopophos, Bristol-Myers Squibb) has been developed as a prodrug.

Etoposide phosphate is the phosphate ester derivative of etoposide, in comparison to the parent compound, etoposide phosphate is highly soluble in water and can be readily formulated for intravencus uso resulting in higher ctinical application. This paper presents information on the pharmaceutical properties and the current status of etoposide phosphate in clinical triafs.

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Authors and Affiliations

  1. Dept. of Medical Oncology, Antoni van Leetwenhoek Hospital/The netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    J. H. Beijnen

  2. Dept. of Pharmaceutical Analysis & Toxicology, Faculty of Pharmacy, P.O. Box 80.082, 3508 TB, Utrecht, The Netherlands

    J. H. Beijnen

  3. Dept. of Pharmacy, Slotervaart Hospital/Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands

    A. H. I. Witterland & C. H. W. Koks

Authors
  1. A. H. I. Witterland
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  2. C. H. W. Koks
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  3. J. H. Beijnen
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Witterland, A.H.I., Koks, C.H.W. & Beijnen, J.H. Etoposide phosphate, the water soluble prodrug of etoposide. Pharm World Sci 18, 163–170 (1996). https://doi.org/10.1007/BF00820727

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