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Influence of vitamin P upon toxic effects caused by poisons of the accompanying phosphorylation

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Summary

In the presence of quercetin or rutin there is delay, diminution, or even prevention of contractures caused by poisoning associated with phosphorylation. The protecting action is more pronounced against muscle poisoning due to methylene blue and monobromoacetate of sodium, and is weaker against poisoning with dinitrophenol and gramicidin S. So, the more toxic the substance [2], the more difficult it is for vitamin P to protect against its effect.

The influence of quercetin and rutin upon the development of a shielding from the effect of contractures caused by poisoning associated with phosphorylation is selective, since contractures caused by acetylcholine and potassium are not affected.

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Literature Cited

  1. N. V. Golyakhovsky, in the book Works of the Stalingrad Medical Institute In Russian. (Stalingrad, 1947). Vol. 4 pp. 3–30.

  2. E. V. Moreva. Influence of Poisons connected with Phosphorylation upon Skeletal Muscle Contracture Activity, Author's abstract of dissertation In Russian. (Leningrad, 1952).

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Authors and Affiliations

  1. General Pharmacology Group of the Department of Pharmacology of the Institute of Experimental Medicine, Acad. Med. Sci. USSR, Leningrad

    E. V. Moreva

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  1. E. V. Moreva
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Moreva, E.V. Influence of vitamin P upon toxic effects caused by poisons of the accompanying phosphorylation. Bull Exp Biol Med 42, 589–591 (1956). https://doi.org/10.1007/BF00820358

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  • DOI: https://doi.org/10.1007/BF00820358

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