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European Journal of Nuclear Medicine

, Volume 17, Issue 1–2, pp 21–27 | Cite as

Mechanism of gallium 67 accumulation in inflammatory tissue

  • Atsushi Ando
  • Kazuo Nitta
  • Itsuko Ando
  • Shigeru Sanada
  • Shogo Katsuda
  • Norihisa Tonami
  • Tatsunosuke Hiraki
  • Kinichi Hisada
  • Hiroshi Ogawa
Original Article

Abstract

The present study was undertaken to elucidate the accumulation mechanism of gallium 67 in inflammatory tissue.67Ga accumulation in inflammatory tissue was observed by macro- and microautoradiogram. Permeability indices were calculated for serum albumin from blood vessels into inflammatory and normal tissue. Neutrophils and macrophages did not play a major role in67Ga accumulation in the inflammatory tissue because67Ga could hardly be detected in the sites in which neutrophils were crowded; the accumulation was concentrated in the intercellular space around these cells in the tissue. Permeability indices for inflammatory tissue were much greater than those for normal tissues. It is thought from the present study and previously reported results that67Ga, together with plasma from permeable blood vessels, readily penetrates the inflammatory tissue and stays there by binding to the acid mucopolysaccharide present in the tissue.

Key words

Gallium 67 Inflammation Accumulation mechanism Permeability indices Acid mucopolysaccharide 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Atsushi Ando
    • 3
  • Kazuo Nitta
    • 2
  • Itsuko Ando
    • 3
  • Shigeru Sanada
    • 3
  • Shogo Katsuda
    • 1
  • Norihisa Tonami
    • 1
  • Tatsunosuke Hiraki
    • 3
  • Kinichi Hisada
    • 1
  • Hiroshi Ogawa
    • 2
  1. 1.School of MedicineKanazawa UniversityKanazawaJapan
  2. 2.Daiichi Radioisotope Laboratories Ltd.TokyoJapan
  3. 3.School of Allied Medical ProfessionsKanazawa UniversityKanazawaJapan

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