Abstract
It has previously been reported that almost all of the trivalent technetium-99m dimercaptosuccinic acid (99mTc (III) DMSA) present in the labelling product of pentavalent technetium-99m DMSA (99mTc (V) DMSA) can be changed into99mTc (V) DMSA by bubbling with pure oxygen. We therefore performed studies in animals (mice) and humans to investigate the effect of such oxygen bubbling on the labelling efficiency of and on the renal uptake of99mTc. The method of labelling of99mTc (V) DMSA was that of Hirano. It was found that oxygen bubbling oxidized the contaminated99mTc (III) DMSA into99mTc (V) DMSA in vitro and decreased the uptake of radioactivity in the kidney in both animals and humans.
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Kobayashi, H., Horiuchi Suzuki, K., Sakahara, H. et al. Oxygen bubbling can improve the labelling of pentavalent technetium-99m dimercaptosuccinic acid. Eur J Nucl Med 22, 559–562 (1995). https://doi.org/10.1007/BF00817283
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DOI: https://doi.org/10.1007/BF00817283