European Journal of Nuclear Medicine

, Volume 22, Issue 6, pp 532–536 | Cite as

Estimation of glomerular filtration rate and technetium-99m diethylene triamine penta-acetic acid using chromium-51 ethylene diamine tetra-acetic acid

  • Alberto Biggi
  • Anna Viglietti
  • Maria Chiara Farinelli
  • Claudio Bonada
  • Gianfranco Camuzzini
Original Article

Abstract

Simultaneous measurements of the clearance rate of chromium-51 ethylene diamine tetra-acetic acid (51Cr-EDTA) and technetium-99m diethylene triamine penta-acetic acid (99mTc-DTPA) were performed in 54 patients with a range of function between 9 and 176 ml/min. Using multiple blood samples the two clearance values correlated well (r = 0.97, SEE 8.6 ml/min) and DTPA clearance was higher by 2.9%. For each radiopharmaceutical the plasma clearance rates obtained using multiple blood samples were compared with those obtained with simplified methods, i.e., the 60–180 min two-sample method of Russell and the mono-exponential method with the Brochner-Mortensen correction. For both radiopharmaceuticals the clearance values correlated well with the Russell method (r = 0.99, SEE = 4.1 ml/min for EDTA;r = 0.99, SEE 4.9 ml/min for DTPA) and the mono-exponential method (r = 0.99, SEE 3.6 ml/min for EDTA;r = 0.99, SEE 3.9 ml/min for DTPA). The mean plasma clearance obtained using multiple blood samples did not differ significantly from that obtained with the Russell method, either in patients with a glomerular filtration rate (GFR)<30 ml/min or in patients with GFR≥30 ml/min. The mean plasma clearance obtained using multiple blood samples differed significantly from that obtained with the mono-exponential method because of the great difference observed in patients with GFR≥30 ml/min. It is concluded that the Russell two-sample method after injection of99mTc-DTPA is accurate enough for routine clinical use.

Key words

Glomerular filtration rate Plasma clearance rate Chromium-51 ethylene diamine tetra-acetic acid Technetium-99m diethylene triamine penta-acetic 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Alberto Biggi
    • 1
  • Anna Viglietti
    • 1
  • Maria Chiara Farinelli
    • 1
  • Claudio Bonada
    • 1
  • Gianfranco Camuzzini
    • 1
  1. 1.Department of Nuclear MedicineS. Croce General HospitalCuneoItaly

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