European Journal of Nuclear Medicine

, Volume 22, Issue 6, pp 505–507 | Cite as

Rhenium-188 sulphur colloid as a radiation synovectomy agent

  • Shyh-Jen Wang
  • Wan-Yu Lin
  • Bor-Tsung Hsieh
  • Lie-Hang Shen
  • Zei-Tsan Tsai
  • Gann Tinge
  • Furn F KnappJr.
Original Article


Radiation synovectomy has been shown to be an effective treatment for the rheumatoid arthritic knee. In this study, we evaluated the suitability of rhenium-188 as a radiation synovectomy agent. In addition, we were successful in labelling sulphur colloid with188Re. In vitro stability tests revealed that more than 95% of the188Re remained in colloid form over a 3-day period. Intra-articular injection of188Re sulphur colloid into arthritic rabbit joints was followed by gamma camera imaging to quantify the leakage. The mean retention percentages of188Re colloid in arthritic knees were 93.7% (±1.4%), 90.8% (±1.7%) and 87.2% (±0.6%) at 1 h, 1 day and 2 days, respectively. A biodistribution study of the arthritic rabbits revealed that the highest activity outside the knees was in the liver and the kidneys. Our preliminary results indicate that 188Re sulphur colloid may be an effective radiopharmaceutical for radiation synovectomy.

Key words

Radiation synovectomy Rhenium-188 colloid Rheumatoid arthritis 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Shyh-Jen Wang
    • 1
    • 4
  • Wan-Yu Lin
    • 1
  • Bor-Tsung Hsieh
    • 2
  • Lie-Hang Shen
    • 2
  • Zei-Tsan Tsai
    • 2
  • Gann Tinge
    • 2
  • Furn F KnappJr.
    • 3
  1. 1.Department of Nuclear MedicineTaichung Veterans General HospitalTaichungTaiwan
  2. 2.Institute of Nuclear Energy ResearchTaiwan
  3. 3.Oak Ridge National LaboratoryUSA
  4. 4.National Yang-Ming Medical CollegeTaipeiTaiwan

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