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Monatshefte für Chemie / Chemical Monthly

, Volume 122, Issue 1–2, pp 43–46 | Cite as

Oxadiazole condensed ring systems, II: Synthesis of new 2-aryl-1,3,4-oxadiazolo[3,2-a]-s-triazine-5,7(6H)-diones

  • Ahmed M. M. Hassan
  • El-Sayed A. M. Badawey
Organische Chemie Und Biochemie

Summary

The syntheses of 1,3,4-oxadiazolo[3,2-a]-s-triazine-5,7(6H)-diones4 through the condensation of 2-amino-5-aryl-1,3,4-oxadiazoles1 with ethoxycarbonyl isocyanate2 is described. Methylation of4b with trimethyl phosphate yielded the N-methyl derivative5.

Keywords

2-Amino-1,3,4-oxadiazoles Ethoxycarbonyl isocyanate 1,3,4-Oxadiazolol[3,2]-a]-s-triazine-5,7(6H)-diones 

Kondensierte Ringsysteme des Oxadiazols, 2. Mitt. [1]: Synthese von neuen 2-Aryl-1,3,4-oxadiazolo[3,2-a]-s-triazin-5,7(6H)-dionen

Zusammenfassung

Die Synthese von 1,3,4-Oxadiazolo[3,2-a]-s-triazin-5,7(6H)-dionen4 durch Kondensation von 2-Amino-5-aryl-1,3,4-oxadiazolen1 mit Ethoxycarbonylisocyanat2 wird beschrieben. Die Methylierung von4b mit Trimethylphosphat gibt das N-Methyl-Derivat5.

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References

  1. [1]
    For Part I see: Badawey E.-S. A. M., Hassan A. M. M., Soliman F. S. G. (1990) Monatsh. Chem.121: 665Google Scholar
  2. [2]
    Bhattacharya B. K., Singh H., Yadav L. D. S., Hoornaert G. (1982) Acta Chim. Acad. Sci. Hung.110: 133; (1983) C. A.98: 34505 bGoogle Scholar
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    Singh H., Yadav L. D. S., Sharma K. S., Singh A. K. (1983) Indian J. Chem.22 B: 1177Google Scholar
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    Singh H., Yadav L. D. S., Shama K. S., Chaudhary J. P. (1984) Acta Chim. Hung.115: 377; (1984) C. A.101: 708Google Scholar
  5. [5]
    Badawey E.-S. A. M., Rida S. M., Soliman F. S. G., Kappe T. (1989) J. Heterocycl. Chem.26: 405Google Scholar
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    Gehlen H., Simon B. (1984) Arch. Pharm.303: 511Google Scholar
  7. [7]
    Conducted in the Department of Microbiology, Medical Research Institute, University of Alexandria, EgyptGoogle Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Ahmed M. M. Hassan
    • 1
  • El-Sayed A. M. Badawey
    • 1
  1. 1.Department of Pharmaceutical Chemistry, Faculty of PharmacyUniversity of AlexandriaAlexandriaEgypt

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