Amino Acids

, Volume 7, Issue 2, pp 117–127 | Cite as

Plasma membrane guanylate cyclase is a multimodule transduction system

  • R. K. Sharma
  • T. Duda
  • A. Sitaramayya
Minireview Article


This minireview highlights the studies which suggest that guanylate cyclase is a single-component transducing system, containing distinct signaling modules in a single membrane-spanning protein. A guanylate cyclase signaling model is proposed which envisions the following sequential events: (1) a signal is initiated by the binding of the hormone to the ligand binding module; (2) the signal is potentiated by ATP at ARM; and (3) the amplified signal is finally transduced at the catalytic site. All of these signaling steps together constitute a switch, which when turned on, generates the second messenger cyclic GMP.


Amino acids Guanylate cyclase ATP-Regulatory Module Atrial natriuretic factor receptor Type C natriuretic factor receptor 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • R. K. Sharma
    • 1
  • T. Duda
    • 1
  • A. Sitaramayya
    • 2
  1. 1.The Unit of Regulatory and Molecular BiologyPennsylvania College of OptometryPhiladelphiaUSA
  2. 2.Eye Research InstituteOakland UniversityRochesterUSA

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