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The unraveling architecture of the junctional sarcoplasmic reticulum

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Abstract

The sarcoplasmic reticulum (SR) of skeletal muscle controls the contraction-relaxation cycle by raising and lowering the myoplasmic free-Ca2+ concentration. The coupling between excitation, i.e., depolarization of sarcolemma and transvers tubule (TT) and Ca2+ release from the terminal cisternae (TC) of SR takes place at the triad. The triad junction is formed by a specialized region of the TC, the junctional SR, and the TT. The molecular architecture and protein composition of the junctional SR are under active investigation. Since the junctional SR plays a central role in excitation-contraction coupling and Ca2+ release, some of its protein constituents are directly involved in these processes. The biochemical evidence supporting this contention is reviewed in this article.

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  1. Department of Physiology and Biophysics, University of Texas, Medical Branch, 77550, Galveston, Texas

    Pompeo Volpe

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Volpe, P. The unraveling architecture of the junctional sarcoplasmic reticulum. J Bioenerg Biomembr 21, 215–225 (1989). https://doi.org/10.1007/BF00812069

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