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Determination of nisoldipine in film tablets by differential pulse polarography

Gehaltsbestimmung von Nisoldipin in Filmtabletten mittels differentieller Pulspolarographie

  • Anorganische Und Physikalische Chemie
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Summary

A differential pulse polarographic (DPP) method was developed for the determination of nisoldipine in Baymycard® film tablets without interference from excipients. Nisoldipine is reduced at the dropping mercury electrode in a single, irreversible peak. Linearity between the nisoldipine concentration and the peak height was observed in the 5·10−4–10−7 M concentration range. The detection limit is 22 ng/ml. The analysis of a series of 10 Baymycard® 5 mg film tablets showed a standard deviation of ±0.115 mg and aS rel of ±2.30%, respectively.

Zusammenfassung

Eine Bestimmung von Nisoldipin in Baymycard® Filmtabletten mittels differentieller Pulspolarographie (DPP) wurde entwickelt, die keine Störungen durch Tablettenhilfsstoffe aufweist. Nisoldipin wird an der tropfenden Quecksilberelektrode in einem einzigen, irreversiblen Peak reduziert. Linearität zwischen Nisoldipinkonzentration und Peakhöhe wurde im Konzentrationsbereich von 5·10−4–10−7 M festgestellt. Die Bestimmungsgrenze beträgt 22 ng/ml. Die Analyse einer Serie von 10 Baymycard® 5 mg Filmtabletten ergab eine Standardabweichung von ±0.115 mg, dies entspricht einerS rel von ±2.30%.

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Authors and Affiliations

  1. Institut für Pharmazeutische Chemie, Universität Graz, A-8010, Graz, Austria

    W. Likussar, A. Michelitsch & M. Schubert-Zsilavecz

Authors
  1. W. Likussar
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  2. A. Michelitsch
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  3. M. Schubert-Zsilavecz
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Likussar, W., Michelitsch, A. & Schubert-Zsilavecz, M. Determination of nisoldipine in film tablets by differential pulse polarography. Monatsh Chem 125, 509–513 (1994). https://doi.org/10.1007/BF00811842

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  • DOI: https://doi.org/10.1007/BF00811842

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