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Hyperkinesis of central origin induced by tetridine and its inhibition by anticholinesterase (choline-sensitizing) agents

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments were performed on guinea pigs and albino mice. An inquiry was made into the effect of cholinesensitizing and cholinolytic substances on the tetridine hyperkinesis in guinea pigs. Tetridine, as is the case with many barbiturates, apart from the anesthetic effect causes stem hyperkinesis in many animals. Cholinolytics (atropine, scopolamine, tropacine, pentaphene, arpenal, ethyldiazyl and methyldiphacyl) do not prevent tetridine hyperkinesis in mice. Atropine and methyldiazyl do not depress hyperkinesis in guinea pigs. Choline-sensitizing (anticholinesterasic) agents depress tetridine hyperkinesis temporarily. This effect may be repeatedly reproduced in the same animal. Inhibition of tetridine hyperkinesis by a choline-sensitizing agent may be prevented by cholinolytic substance, such as atropine.

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Literature Cited

  1. A. I. Beketov, Farmakol. i Toksikol.,21, 4 (1958) p. 3.

    Google Scholar 

  2. D. Bovet and F. Bovet-Nitti, Farmakol. i Toksikol.,22, 3 (1959) p. 201.

    Google Scholar 

  3. R. A. Veis and V. M. Karasik, Fiziol. Zhur. SSSR,33, 2 (1947) p. 229.

    Google Scholar 

  4. I. V. Markova, Fiziol. Zhur. SSSR,36, 2 (1950) p. 161.

    Google Scholar 

  5. I. V. Markova, Farmakol. i Toksikol.,15, 5 (1952) p. 14.

    Google Scholar 

  6. I. V. Markova, Byull. Éksp. Biol. i Med.,40, 10 (1955) p. 47.

    Google Scholar 

  7. M. D. Mashkovskii, Medicinal Agents [in Russian] (Moscow, 1957) p. 20.

  8. Z. F. Ptichkina, in: Collected Scientific Transactions of the Krasnoyarsk Med. Inst., 4 [in Russian] (1955) p. 382.

  9. N. A. Kharauzov, The Pharmacotherapy of Experimental Hyperkinesias of Central Origin. Author's Abstract of Doctor's Dissertation [in Russian] (Leningrad, 1954).

  10. J. A. Cohen and C. H. Posthumus, Acta Physiol. Pharmacol. Neurol.,4 (1955), p. 17.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology of the Leningrad Institute of Pediatric Medicine, Leningrad, USSR

    N. V. Uskova

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  1. N. V. Uskova
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Uskova, N.V. Hyperkinesis of central origin induced by tetridine and its inhibition by anticholinesterase (choline-sensitizing) agents. Bull Exp Biol Med 52, 816–818 (1961). https://doi.org/10.1007/BF00811642

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  • DOI: https://doi.org/10.1007/BF00811642

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