Summary
The effects of PAS and isoniazid on blood cholesterol are ascribed to diversion of active acetyl residues from cholesterol synthesis to acetylation reactions. Thiamine is thought to function as an activator of processes of lipid anabolism. The need for caution in the use of thiamine in treatment of hypertensive disease and atherosclerosis is indicated.
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Literature Cited
O. N. Abbakumova, Collection of Scientific Papers from the Department of Biochemistry of the 1st Leningrad Medical Institute (1958) p. 28.
Yu. S. Kagan, Farmakol. i Toksikol., 6 (1949) p. 16.
G. I. Loibman, Ukr. Biokhim. Zhurn.,24, 1 (1952) p. 19.
I. A. Myasnikova, Trudy Voenno-morsk. Akad. L.,8 (1947) p. 140.
Yu. M. Ostrovskii, D. Z. Kagan, and A. A. Yaroshevich, Byull. Éksper. Biol. i Med.,45, 5 (1958) p. 34.
Yu. M. Ostrovskii, Zdravookhr. Belorussii, 5 (1955) p. 49.
Yu. M. Ostrovskii, Vopr. Med. Khimii, 2 (1957) p. 109.
Yu. M. Ostrovskii, Vopr. Pitaniya, 1 (1957) p. 32.
Yu. M. Ostrovskii, Transactions 2nd Scientific Meeting, Grodno Medical Institute (1960) p. 46.
Yu. M. Ostrovskii, Byull. Éksper. Biol. i Med.,50, 7 (1960) p. 66.
Yu. M. Ostrovskii, Ukr. Biokhim. Zhurn.31 (1959) p. 617.
J. W. Cornforth, Rev. Pure Appl. Chem.,4 (1954) p. 275.
D. Kritchevsky, Cholesterol (New York, 1958).
T. Matsukawa and H. Kawasaki, J. Pharmacol. Soc. Japan,74 (1954), p. 893.
L. J. Reed, J. Am. Chem. Soc.,75 (1953) p. 1267.
J. N. Williams, Fed. Proc.,18 (1959) p. 351.
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Ostrovskii, Y.M. Cholesterol metabolism, acetylation processes, and thiamine. Bull Exp Biol Med 52, 805–807 (1961). https://doi.org/10.1007/BF00811639
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DOI: https://doi.org/10.1007/BF00811639