Monatshefte für Chemie / Chemical Monthly

, Volume 117, Issue 8–9, pp 1011–1020 | Cite as

Die Konzentration an freiem molekularem Jod in wäßrigen PVP-jodhaltigen Systemen und ihre Änderung mit der Temperatur

  • Waldemar Gottardi
  • Waltraud Koller
Organische Chemie Und Biochemie

The concentration of free iodine in aqueous PVP-iodine containing systems and its variation with temperature


The concentration of free iodine and its variation in the temperature range 10–40°C has been determined by the potentiometric method in nine commercial PVP-iodine products as well as in pure aqueous solutions (1, 5 and 10%) of PVP-iodine of the type 17/12 and 90/04. In addition, aqueous solutions of PVP-iodine 30/06 of the same concentrations have been measured in the temperatur range 0–70°C. The commercial products showed a remarkably great spread in the concentration of free iodine (0.2–10 ppm at 25°C), which may be attributed to the different compositions, especially the ratio of total iodine to iodide as well as the kind and quantity of organic-pharmaceutical constituents. All tested PVP-iodine systems showed a significant—and unexpectedly similar—change of the concentration of free iodine by the temperature.

The results concerning its relative alteration fit to an exponential function of the form
$$\Delta \% [I_2 ]_{\Delta t} = 100[10^{(0.23 \pm 0.0026)\Delta t} 1]$$
which is valid from 10 to 40°C. Following this equation [I2] increases about 5.4 resp. 100% if the temperature raises about 1.0 resp. 13.1°C.

This increase of [I2] must be considered in the application of PVP-iodine preparations as disinfectants or antiseptics at living tissues. Because of their higher temperature (c. 30–36°C) the applicated PVP-iodine preparations exhibit a significant higher [I2] than at room temperature (Δt=10–16°C: Δ% [I2]=70–130%).

Therefore also a significant higher degerming efficiency can be expected compared toin vitro experiments, which are conducted in general at room temperature.


Determination of free iodine Disinfection of living tissues Iodine containing disinfectants Providone-iodine preparations 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Waldemar Gottardi
    • 1
  • Waltraud Koller
    • 1
  1. 1.Institut für HygieneUniversität InnsbruckInnsbruckÖsterreich

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