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A convenient semisynthetic route to hypericin

Ein bequemer semisynthetischer Zugang zu Hypericin

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  • Organische Chemie Und Biochemie
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Summary

A semisynthetic route to produce hypericin was established usingCortex frangulae as the starting point. The emodin isolated from it easily and in good yield was reduced to emodin anthrone by means of SnCl2. The latter was reacted via a known oxidative dimerization and photocyclization reaction into hypericin.

Zusammenfassung

Eine semisynthetische Route zur Darstellung von Hypericin unter Verwendung vonCortex frangulae als Ausgangsmaterial wurde erarbeitet. Das daraus einfach und in guten Ausbeuten isolierte Emodin wurde mit Hilfe von SnCl2 zu Emodinanthron reduziert. Letzteres wurde dann über eine bekannte oxidative Dimerisierung und Photocyclisierung zu Hypericin umgesetzt.

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Authors and Affiliations

  1. Institut für Chemie, Johannes Kepler Universität Linz, A-4040, Linz, Austria

    H. Falk, J. Meyer & M. Oberreiter

Authors
  1. H. Falk
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  2. J. Meyer
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  3. M. Oberreiter
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Falk, H., Meyer, J. & Oberreiter, M. A convenient semisynthetic route to hypericin. Monatsh Chem 124, 339–341 (1993). https://doi.org/10.1007/BF00810594

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  • DOI: https://doi.org/10.1007/BF00810594

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