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Synthesis of 4-hydroxy-4,5-dihydro-1,2,4-triazol-5-ones

Synthesen von 4-Hydroxy-4,5-dihydro-1,2,4-triazol-5-onen

  • Organische Chemie Und Biochemie
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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary

A series of hydroxamic acid ethoxycarbonylhydrazides was obtained by reactions of ester ethoxycarbonylhydrazones with hydroxylamine. The corresponding 3-substituted 4-hydroxy-4,5-dihydro-1,2,4-triazol-5-ones were synthesized by cyclization of these hydroxamic acid derivatives in basic medium.

Zusammenfassung

Durch Reaktion von Esterethoxycarbonylhydrazonen und Hydroxylamin wurde eine Reihe von Hydroxamsäureethoxycarbonylhydraziden gewonnen; Cyclisierung dieser Verbindungen durch Base gab die entsprechenden 3-substituierten 4-Hydroxy-4,5-dihydro-1,2,4-triazol-5-one.

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Authors and Affiliations

  1. Department of Chemistry, Karadeniz Technical University, 61080, Trabzon, Turkey

    A. Aykut İkizler & Kemal Sancak

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  1. A. Aykut İkizler
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  2. Kemal Sancak
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İkizler, A.A., Sancak, K. Synthesis of 4-hydroxy-4,5-dihydro-1,2,4-triazol-5-ones. Monatsh Chem 123, 257–263 (1992). https://doi.org/10.1007/BF00810474

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  • DOI: https://doi.org/10.1007/BF00810474

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